The invention discloses a grifolafrondosa and cordyceps militaris drink, belongs to healthcare drinks, and aims to provide a drink which has the effects of reducing blood pressure and fat, protecting the liver and the heart, preventing cancers and resisting ageing, and can effectively prevent and treat diseases such as hypertension, hyperlipidemia, liver diseases, coronary heart diseases and the cancers. The drink is prepared from the following raw materials in parts by weight: 6 parts of grifolafrondosa, 1 part of cordyceps militaris, 2.5 parts of white granulated sugar or xylitol, 50 parts of water and 0.2 parts of xanthan gum. A preparation method for the drink comprises the following steps: soaking the grifolafrondosa and the cordyceps militaris in water for 60 minutes, heating to 50-60 DEG C, keeping the temperature for 60-120 minutes, adding the white granulated sugar or xylitol and xanthan gum into filter liquor, stirring uniformly, and performing sterilization. The drink has the advantages of light medicine flavor, simplicity for preparation, convenience for taking, no toxic effects and the like; the drink can build bodies and improve human immunity after being taken for a long term, and has the effects of resisting and inhibiting the cancers, delaying ageing, prolonging life and the like.