The invention provides an intelligent cooler control system for a transformer. The intelligent cooler control system comprises a current transformer, an oil level temperature measuring meter, an oil outlet temperature measuring meter, a flow indicator, an inlet thermometer, a wind speed sensor and a control box, wherein the current transformer and the oil level temperature measuring meter are arranged on the transformer, the oil outlet temperature measuring meter and the flow indicator are arranged on an output pipeline of an oil pump which is arranged in a cooler, the inlet thermometer is arranged at the position of a fan inlet which is arranged in the cooler, the wind speed sensor is arranged at the position of a fan outlet which is arranged in the cooler, and the control box is provided with a control circuit. An intelligent cooler control method comprises step 1, initializing parameter settings and collecting control parameters; step 2, obtaining the actual cooling capacity of a cooling system and the actual losses of the transformer through calculation according to intrinsic parameters of the transformer and the collected control parameters; step 3, performing comparison on the actual cooling capacity Py of the cooler and the actual losses P of the transformer and controlling the oil pump of the cooler and or a fan according to a comparison result; step 4, repeating the step 2 and the step 3 according to the intrinsic parameters of the transformer and the timely-collected control parameters until the oil pump and the fan reach the operation state when Py is equal to P in the step 3.