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发明公开
CN104650113A 类美登素衍生物及其制备方法和用途 无效 - 撤回

类美登素衍生物及其制备方法和用途
摘要：
本发明为类美登素衍生物及其制备方法和用途，提供可以连接到抗原结合单元(Abu)的类美登素药物连接子衍生物以及连有抗原结合单元的类美登素药物(药物-连接子-抗原结合单元：D-L-Abu)，以期实现靶向释放给致病组织。提供D-L-Abu、D-L-Abu衍生物以及关于使用此类药物偶联物治疗癌症和免疫异常中抗原阳性细胞的方法。
摘要（英）：

The invention discloses a maytansine derivative as well as a preparation method and an application thereof. A maytansine medicine connector derivative connected with an antigen binding unit (Abu) and a maytansine medicine (medicine-connector-antigen binding unit: D-L-Abu) connected with the antigen binding unit are provided for realizing the target release on the pathogenic tissues. A D-L-Abu, a D-L-Abu derivative and a method for treating the antigen-positive cells in the cancer and the dysimmunity by using the medicine conjugate are provided.

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