The invention discloses a mixing loose tube type layer-stranding optical cable and a manufacturing method of the mixing loose tube type layer-stranding optical cable and further discloses a manufacturing device of the mixing loose tube type layer-stranding optical cable. The optical cable comprises a metal damp-proof layer and a yarn bundling layer which are arranged on the inner layer of a sheath layer in sequence from outside to inside, at least one loose tube and at least one central reinforcing piece are arranged in the yarn bundling layer, at least one optical fiber bundle or an optical fiber band is arranged in the loose tube, the loose tube is wound around the periphery of the central reinforcing piece long in the longitudinal direction through SZ stranding, and a gap of the loose tube with the optical fiber bundle or the optical fiber band arranged inside is filled with an optical fiber bundle loose tube with a small number of cores. The manufacturing method comprises the steps that the central reinforcing piece, the loose tube with the optical fiber bundle or the optical fiber band arranged inside and the optical fiber loose tube with the small number of cores through a yarn model and a stranding table and are pulled to a yarn bundling table, and a cable core is driven by a crawler to be synchronously pulled to a cable core take-up stand. The mixing loose tube type layer-stranding optical cable and the manufacturing method of the mixing loose tube type layer-stranding optical cable have the advantages that the cable core is simple in structure, round and small in outer diameter, the intensity of optical fibers in unit section is high, and the pipeline resource utilization rate is high.