The invention provides a universal protective seal plug for a pipe hole. The universal protective seal plug for the pipe hole comprises two sets of plugging modules which are formed by being assembled in a cross-overlap mode; each plugging module is a semicircular cylinder, and the plugging modules are assembled in a butt-joint mode to form a cylindrical structure used for plugging. Sub-rings with different specifications are contained in the plugging modules and connected in a sleeving mode. When needing to plug a cable with a certain specification, the cable installation personnel only need to find out the sub-ring corresponding to the specification of the cable and then cut the connecting portion, on the inward side, of the sub-ring. The semicircular annular thin layer connecting structures among the sub-rings can be cut quickly and conveniently. Only one ends of the separated sub-rings which are connected in an overlapping mode need to be connected, and when plugging is performed, the close connection among the sub-rings can be achieved due to the existence of the connecting portions. By adopting the universal protective seal plug for the pipe hole, construction can be performed only needing to cut one end of the connecting portion and without needing to cut two ends or even the side face structure of the whole seal plug, and operation is easy and convenient.