The invention discloses a dynamic rotary sterilization cabinet, and belongs to the field of sterilization cabinets. The sterilization cabinet comprises a shell and a cylinder; the two ends of the cylinder are respectively provided with a material inlet and a material outlet; a spiral material guide groove is arranged on the internal wall of the cylinder; the cylinder is movably supported in the shell and is connected to a driving component, the material from the material inlet can move along the spiral material guide groove towards the material outlet; the external surface of the cylinder is covered by a heating sheet that can heat the cylinder; a steam generating component is arranged on the shell, the output terminal of the steam generating component is connected to a multifunctional pipe in the cylinder, the multifunctional pipe is provided with a plurality of through holes, the water inlet of a water pump is communicated with a water tank, the water outlet pipe of the water pump is connected to the multifunctional pipe, and the clear water, which is pressurized by the water pump, can be sprayed out from the through holes in the multifunctional pipe to wash the internal wall of the cylinder. The dynamic rotary sterilization cabinet has the advantages that the materials can be heated evenly, the materials do not be agglomerated together, the energy consumption is low, the on-line washing can be carried out automatically, and the cabinet can be applied to massive production.