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发明公开
CN104774902A 一种发酵过程优化与放大的方法与装置 无效 - 驳回

一种发酵过程优化与放大的方法与装置
摘要：
本发明提供一种对生物反应器进行过程优化和数据放大的方法，所述方法包括：(a)测定所述生物反应器装置的所述发酵过程中的生理代谢参数、生理代谢参数相关特性或其组合；其中所述生理代谢参数选自：溶氧、摄氧率、呼吸商、体积氧传递系数或其组合；(b)将步骤(a)测定的所述生理代谢参数、生理代谢参数相关特性与预定值的生理代谢参数、生理代谢参数相关特性或其组合进行比较；选出与所述预定值最为接近的生物反应器装置；确定优化的放大生物反应器装置；其中所述生理代谢参数如步骤(a)所述。
摘要（英）：

The invention provides a process optimization and data amplification method for a bioreactor. The method comprises the following steps: (a) determining physiological metabolic parameters, physiological metabolic parameter related characteristics or combination thereof in the fermentation process of the bioreactor, wherein the physiological metabolic parameters are selected from dissolved oxygen, oxygen uptake rate, respiration quotient, volumetric oxygen transfer coefficient or combination thereof; and (b) comparing the physiological metabolic parameters and physiological metabolic parameter related characteristics determined in the step (a) with preset physiological metabolic parameters and physiological metabolic parameter related characteristics or combination thereof; selecting the bioreactor device of which the physiological metabolic parameters and physiological metabolic parameter related characteristics are closest to the preset values; and determining the optimized amplification bioreactor device, wherein the physiological metabolic parameters are represented in the step (a).

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