The present invention relates to a lignocellulosic feedstock pretreatment method without prepreg. The method comprises the specific steps of: (1) pretreating the lignocellulosic feedstock by dedusting and crushing; (2) preparing acid, alkali and salt solution or an organic solvent; (3) adding the materials obtained in the step (1) and the ) chemical solution or solvent obtained in step (2) into a pretreatment reactor for pretreatment; and (4) conducting subsequent processing steps such as enzymatic hydrolysis or simultaneous saccharification and fermentation on the pretreated lignocellulosic feedstock obtained in the step (3). The invention has the advantage that the pretreatment without prepreg, in the premise of ensuring the pretreatment effect, simplifies the operation complexity of the pretreatment process, greatly shortens the time for pretreatment and improves the operational efficiency of pretreatment; at the same time, the method save the invest for fixed equipment such as prepreg reactor, and dramatically reduces the cost of lignocellulose pretreatment and final biorefinery production process of bio-based chemicals.