The invention relates to a seal remote operation system based on the Internet of things. A seal safekeeping box is connected with a cloud server, and communicates with a mobile phone client through the cloud server. The cloud server is composed of a control server and a video server. The seal safekeeping box is provided with an unlocking controller, a door magnet and an application button, all of which are connected with a network camera. The network camera is connected with a wireless router. A seal connected by a thin steel wire is placed in the seal safekeeping box. The length of the thin steel wire makes the seal freely move in the shooting range of the network camera. By adopting the seal remote operation system based on the Internet of things and an operation method thereof, a seal owner can receive seal taking information in real time even when the seal owner is not on the scene, the use of seals can be remotely authorized, and the seal using process can be monitored in real time, so as to achieve the purpose of seal safekeeping, taking and using whole-process control.