The invention discloses a human body cooling device for O2O (online-to-offline) regulation, wearable human body cooling equipment and a human body cooling method. The human body cooling device is characterized in that a hollow containing cavity of the human body cooling device is filled with cooling fluid; when a human body needs to be cooled, a control unit controls a driving unit to move, and the driving unit drives a spray unit to spray a preset quantity of cooling fluid from the containing cavity and drives an applying unit to apply the cooling liquid on human body parts to be cooled, so that physical cooling of the human body is achieved. The human body cooling device for O2O regulation has the advantages that the human body cooling device is used for O2O physical cooling of the human body and capable of completing a whole process automatically without artificial participation, and accordingly, human body temperature can be regulated conveniently and considerately, and people's life is facilitated.