The invention discloses a brain-targeted intranasal administration apparatus and a body position fixing device thereof. The brain-targeted intranasal administration apparatus comprises the body position fixing device and an administration device. The body position fixing device is used for keeping the body position of a user in a state that drugs administrated through a nasal cavity can enter a specific olfactory region in the upper nasal cavity. The administration end of the administration device has a shape matching the nasal cavity of the user. The administration device is used for administrating the drugs to the user under a condition that the body position fixing device keeps the user in the body position mentioned above, and the drugs are directed into the brain. Specifically, the body position fixing device comprises a head holder used for bearing the head of the user and keeping the head in a state that the drugs administrated through the nasal cavity can enter the olfactory region in the upper nasal cavity. The head holder comprises a headrest, supports and a middle axle rod, wherein the headrest is used for bearing the head of the user, and the headrest is rotatably supported on the supports through the middle axle rod. The user is kept in the specific administration body position, and the administration apparatus is controlled by intelligent elements, so that the drugs administrated through the nasal cavity can enter the olfactory region in the upper nasal cavity at a fixed time, with fixed speed, and with fixed quantify, and the drugs are targeted to the brain.