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发明公开
CN104884082A 用作诱导抗原特异性T细胞反应的免疫原性增强剂的融合蛋白 失效 - 权利终止

用作诱导抗原特异性T细胞反应的免疫原性增强剂的融合蛋白
摘要：
本发明公开了一种疫苗组合物，其包含用于诱导增强的病原体抗原特异性T细胞反应的融合蛋白。所述融合蛋白包含：(a)抗原呈递细胞(APC)结合域或CD91受体结合域，其位于融合蛋白的N端；(b)长度为34-112个氨基酸残基的转位肽，其包含与SEQ ID NO:4、SEQ ID NO:2、SEQ ID NO:3或SEQ ID NO:6至少90％相同的氨基酸序列，其位于APC结合域或CD91受体结合域的C端；(c)病原体的抗原，其位于转位肽的C端；(d)核输出信号，其包含SEQ ID NO:13的氨基酸序列；及(e)内质网滞留序列，其位于融合蛋白的C端。
摘要（英）：

A vaccine composition comprising a fusion protein for inducing enhanced pathogen antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain, located at the N-terminus of the fusion protein; (b) a translocation peptide of 34-112 amino acid residues in length, comprising an amino acid sequence that is at least 90% identical to SEQ ID NO: 4, 2, 3, or 6, located at the C-terminus of the APC-binding domain or the CD91 receptor-binding domain; and (c) an antigen of a pathogen, located at the C-terminus of the translocation peptide; (d) a nuclear export signal, comprising the amino acid sequence of SEQ ID NO: 13; and (e) an endoplasmic reticulum retention sequence, located at the C-terminus of the fusion protein.

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