The invention discloses a control method of a full-bridge converter of asymmetric duty ratios. Upper and lower switching tubes of left and right bridge arms in a full bridge are in complementary conduction, but the conduction duty ratio of each switching tube is not 0.5, i.e., the duty ratios of the upper and lower switching tubes are asymmetrical; at the same time, in each period, the state sequence of a primary side of a transformer is +1, -1 and 0, i.e., the voltage sequence of the primary side of the transformer is Vin, -Vin and 0; and in addition, an output rectifier is directly connected with a load without an inductor filter. The control method of the full-bridge converter of asymmetric duty ratios can effectively shorten the time of fall of leakage inductance current of the primary side of the transformer, suppresses power reflux, reduces reactive power, and obviously improves system efficiency.