The invention relates to an intelligent prediction control system for vehicle control. The system comprises three parts for information acquisition, intelligent prediction central processing and drive control. The system integrates vehicle travel information, historical road condition data, traffic condition prediction, weather condition on road, etc. to predict vehicle travel mileage, to properly arrange for use of stored power and to make a power generation strategy. It can predict the mileage that can be covered by stored power with high accuracy and safely and reliably, maximize the continuing mileage of the power and its advantages of environment protection over others. In light of the road condition prediction, on roads with varied slopes, the vehicle preferably uses the stored power and reserves power properly when traveling down slopes. For hybrid-power vehicles, when it predicts that the power cannot afford a complete run, the system can remind the driver of initiating at smooth sections of a road other drive power or of charging power. For vehicles using traditional energy, the system will preferably choose the shortest route or the road for shortest time so as to maximally reduce energy consumption and to increase the environmental-friendliness and economy of the vehicles.