The invention belongs to the technical field of medicines, and in particular relates to a 9-hydroxytanshinone IIA sodium sulfonate ester derivative of a formula 1. The derivative has the structure characteristics that R is the 9-hydroxytanshinone IIA sodium sulfonate ester derivative consisting of hydrocarbyl groups with 1-8 carbon atoms, and the configuration of a 9-site carbon atom is R, an S-configuration mixture or a single optical monomer. The compound provided by the invention, by virtue of transcription and expression of inflammation inhibitory media, can reduce the release of inflammation induced inflammatory media and inhibit the regulation mechanism of cell inflammation, has an obvious anti-inflammatory action on inflammation related diseases, and can be used for preparing medicaments for preventing and treating inflammation related cardiovascular diseases.