The invention discloses a making method and product of pure giant salamander meat meal. The method integrates the enzymatic degreasing technology, the enzymolysis limiting technology and the ultrahigh-pressure cold sterilization technology, is simple in process, high in enzymolysis efficiency and moderate in condition, protects heat sensitive ingredients and nutritious ingredients in salamander meat against damage, increases flavor substances and enhances the taste and flavor of the salamander meat meal. The giant salamander meat meal produced through the method is high in solubility and delicious in flavor and can be applied to seasonings or directly eaten.