The invention discloses a preparation method for berberine hydrochloride micro-capsules. The method comprises the following steps that 1, ethyl cellulose powder is dissolved into a volatile organic solvent to obtain a solution a; 2, in the stirring state, berberine hydrochloride powder and pore-foaming agent polyethylene glycol 4000 are added to the solution a to obtain a solution b; 3, an emulsifier span is dissolved into a non-volatile high-boiling-point liquid at the dissolving temperature being 20-45 DEG C to obtain a solution c, and the mass percentage concentration of the span in the solution c is 0.5%-5.5%; 4, at the temperature of 20-45 DEG C, the solution b is added to the solution c for stirring for 3-6 h, then extraction filtering is performed, solid is washed by petroleum ether, and natural drying is performed at room temperature. The berberine hydrochloride micro-capsules can shield the bitter taste of berberine hydrochloride, and the obedience of a sick child is improved; and the half-life period of the berberine hydrochloride medicine is prolonged, the bioavailability of the medicine is improved, and the acting time of the medicine is prolonged.