Provided is an application of a sulfonamides compound (i.e. the compound represented by general formula I) in chronic airway inflammatory diseases, particularly the use of Compound A or analogues thereof (Compound A1), for preparing a pharmaceutical composition treating diseases related to chronic airway inflammation. Compound A or analogues thereof of the present invention can reduce invasion and recruitment of inflammatory cells, particularly neutrophil granulocyte, and induce apoptosis of inflammatory cells, thus being used for chronic airway diseases such as bronchial asthma and COPD, and particularly for the treatment of chronic airway diseases where glucocorticoid has no effect.