The invention belongs to the field of pharmaceutical preparations and particularly relates to a vonoprazan fumarate enteric coated tablet and a preparation method thereof. The invention adopts the following technical scheme: vonoprazan fumarate and pharmaceutical auxiliary materials are prepared into tablet cores, and then an enteric layer is coated; every 1000 tablet cores comprise 13.36g of vonoprazan fumarate, 40-50g of mannitol, 10-20g of microcrystalline cellulose, 3-8g of hydroxypropyl vonoprazan fumarate enteric coated tablet cellulose, 1-5g of fumaric acid, 8-30g of croscarmellose sodium and 1-3g of magnesium stearate; every 1000 enteric film-coated layers comprise 7.0g of acrylic resin, 0.1g of triethyl citrate and 3.9g of talcum powder. The technical scheme provided by the invention solves the problem that the release of common tablets in the stomach is unstable.