The invention discloses dendrobium officinale yellow wine. The dendrobium officinale yellow wine is prepared from 70%-80% of high-quality base liquor, 6%-10% of dendrobium officinale, 2%-6% of radix pueraiae, 1%-3% of fructus lycii, 1%-3% of semen cassia and the balance of drinking water. The dendrobium officinale yellow wine prepared through the formula and the method is rich in nutrition, contains amino acid, sugar, vinegar, organic acid and multiple kinds of vitamins which are generated by fermentation of the yellow wine and further contains benzene dendrobium officinale A-R, phenol, lignin and lactone compounds, isoflavone puerarin, triterpene gezao alcohol and multiple microelements such as zinc, copper, ferrum, manganese, nickel, chromium, magnesium, lead, calcium and potassium. The dendrobium officinale yellow wine is bright in color and luster, strong in medicine fragrance and soft in taste and has the functions of improving eyesight, tonifying the kidney, enhancing the immunity of a human body and the like.