The invention discloses an irbesartan hydrochlorothiazide tablet. The tablet is composed of irbesartan, hydrochlorothiazide, croscarmellose sodium, lactose, microcrystalline cellulose and magnesium stearate according to the mass ratio of (140-160):(11-14):(10-50):(10-33):(21-59):(2-3). The invention further provides a method for preparing the irbesartan hydrochlorothiazide tablet. According to the method, first the disintegrant croscarmellose sodium, irbesartan and lactose undergo joint wet granulation, are dried and then crushed and screened to obtain premix, and then the premix is mixed with hydrochlorothiazide and microcrystalline cellulose to undergo wet granulation again. The method enhances mobility and miscibility of irbesartan fines, and irbesartan is evenly mixed with hydrochlorothiazide more easily. The tablet has the advantages of being high in dissolution rate and uniformity.