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发明公开
CN105078891A 一种TAK-438脂质体及其制备方法和应用 有权 质押

一种TAK-438脂质体及其制备方法和应用
摘要：
本发明提供一种TAK-438脂质体，包括以下质量份数的原料：卵磷脂或大豆磷脂25-80份，胆固醇5-25份，成膜溶剂8-25份，TAK-438 0.5-2.5份，缓冲液20-60份。本发明的TAK-438脂质体所用原料无毒，易得，TAK-438脂质体稳定性高，脂质体中药物的溶解度和生物利用度高，脂质体中的TAK-438的抗酸作用可以得到更好地发挥。本发明TAK-438脂质体制备方法简单，操作简便，易于工业生产。本发明TAK-438脂质体适用于抑制胃酸相关性疾病。
摘要（英）：

The invention provides a TAK-438 liposome which comprises the following raw materials in parts by mass: 25-80 parts of lecithin or soybean lecithin, 5-25 parts of cholesterol, 8-25 parts of a film forming solvent, 0.5-2.5 parts of TAK-438 and 20-60 parts of a buffer solution. The raw materials used by the TAK-438 liposome provided by the invention are non-toxic and easy to obtain, the TAK-438 liposome has high stability, the solubility and bioavailability of medicines in the liposome are high, and the anti-acid effect of TAK-438 in the liposome can be better exerted. The TAK-438 liposome provided by the invention is simple in preparation method, simple and convenient to operate, and easy to realize industrial production. The TAK-438 liposome provided by the invention is suitable for inhibiting gastric acid related diseases.

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