The invention discloses a purification method of chromatographic grade methanol. The method is characterized in that impurities in a raw material methanol are removed through processes such as modified active carbon adsorption and the like so as to obtain chromatographic grade methanol. By the purification method of chromatographic grade methanol, methanol with its purity being greater than or equal to 99.99 wt% can be obtained. The method meets high-purity requirement of a chromatographic grade reagent. Methanol obtained after purification can be applied in fields of chromatographic analysis, chromatographic separation, chromatographic preparation and the like. The application range of methanol is broadened.