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发明公开
CN105085520A 3-(2-硝基-1-苯乙基)-2-(2-苯基咪唑并[1,2-α]吡啶)类化合物 失效 - 权利终止

3-(2-硝基-1-苯乙基)-2-(2-苯基咪唑并[1,2-α]吡啶)类化合物
摘要：
本发明公开了一种3-(2-硝基-1-苯乙基)-2-(2-苯基咪唑并[1,2-α]吡啶)类化合物及其制备方法，该化合物的结构通式为： ，制备方法如下：在无水无氧条件下，将2-芳基咪唑并[1,2-α]吡啶和β-硝基苯乙烯加入叔丁醇中，在氩气环境下、80℃反应12~24小时，反应结束后减压浓缩，进行色谱分离，得到目标产物。所得化合物结构中的咪唑并[1,2-α]吡啶基团本身就具有良好的药物活性，经过修饰后的结构，可为其在生物活性方面的研究提供技术支持。另外该反应过程中不使用金属催化剂及添加剂，易于纯化，成本低廉。
摘要（英）：

The present invention discloses a 3-(2-nitro-1-phenylethyl)-2-(2-phenyl-imidazo[1,2-alpha pyridine) compound and a preparation method thereof. The compound has a structural formula as below. The preparation method is as below: adding 2-aryl-imidazo[1,2-alpha]pyridine and beta-nitrostyrene into tert-butanol under anhydrous oxygen-free and water-free condition; reacting under argon atmosphere at 80 DEG C for 12-24 h; after the reaction, concentrating under reduced pressure; and conducting chromatographic separation to obtain the desired product. The imidazo[1,2-alpha]pyridyl group in the obtained compound has excellent pharmacological activity; and the modified structure can provide technical support in the research on biological activity. In addition, the reaction process does not use metal catalyst or additive, and is easy for purification and low in cost.

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