The invention relates to an instant domestic fungus soup, concretely relates to an instant domestic fungus soup with brain strengthening and intelligence developing efficacies, and a making method thereof, and belongs to the technical field of food processing. The main material of the instant domestic fungus soup comprises, by weight, 400-450 parts of needle mushroom, 60-100 parts of Pleurotus ostreatus, 60-100 parts of Pleurotus eryngii, 60-100 parts of Agaricus bisporus, 60-100 parts of Pleurotus nebrodensis, 60-100 parts of Grifola frondosa, 5-10 parts of Cordyceps militaris, 60-80 parts of spinach and 80-100 parts of carrot. The content of domestic fungi in the instant domestic fungus soup made in the invention reaches up to 80% or more, and the instant domestic fungus soup has the characteristics of abundant nutrition, pure mouthfeel, uniform but not turbid soup, bright appearance, and abundant content of lysine, has brain strengthening and intelligence developing efficacies, can improve the human body immunity, allows consumers to fast and conveniently obtain high-quality nutrients, adjusts the diet structure of the consumers and improves the diet quality of the consumers.