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发明授权
CN105112375B 杂交瘤细胞株ZJED0-02、抗埃博拉病毒GP蛋白单克隆抗体及其制备和应用 有权

杂交瘤细胞株ZJED0-02、抗埃博拉病毒GP蛋白单克隆抗体及其制备和应用
摘要：
本发明涉及杂交瘤细胞株ZJED0‑02、抗埃博拉病毒GP蛋白单克隆抗体及其制备和应用。本发明杂交瘤细胞株ZJED0‑02可用于分泌抗埃博拉病毒GP蛋白单克隆抗体。该单克隆抗体与博拉病毒GP蛋白的第411‑490位氨基酸序列抗原肽具有高的特异性和灵敏性，可应用于制备埃博拉病毒GP蛋白检测试剂。本发明还完成了对单克隆抗体的测序，为单克隆抗体序列的人源化改造，研发具有中和埃博拉病毒的中和抗体，为后期发展成为临床治疗埃博拉病毒病抗体奠定物质基础。
摘要（英）：

The invention relates to a hybridoma cell strain ZJED0-02, an anti-Ebola virus GP (glycoprotein) monoclonal antibody and their preparation and application. The hybridoma cell strain ZJED0-02 is applicable to secreting the anti-Ebola virus GP monoclonal antibody. The monoclonal antibody is highly specific and sensitive to 411th to 490th amino acid sequence antigen peptides of Ebola virus GP and is applicable to the preparation of Ebola virus GP detection reagents. The invention also finishes sequencing of the monoclonal antibody, a neutralizing antibody capable of neutralizing Ebola virus is developed for humanization of monoclonal antibody sequences, and material basis is laid of late development of the neutralizing antibody into antibodies for clinically treating Ebola virus diseases.

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