The invention provides a method for preparing stable type sesamol microemulsion. Isoamyl acetate serves as an oil phase, the emulsifying agent dodecyl trimethyl ammonium chloride and Span80 are added, and ultrasonic even mixing is carried out; a prepared absolute ethyl alcohol solution containing sesamol and a KCl solution are added into the solution respectively in sequence to be evenly mixed, and the clear and transparent microemulsion containing certain concentration of sesamol is obtained. The radius of a liquid drop of the product is 1-100 nm, stability is good, and the product is free of the layering phenomenon when stored for a long time at the room temperature.