The present invention discloses a method and device for preprocessing message addresses in a protocol processing pipeline. The method comprises the steps: dividing messages to be processed into N groups according to a preset rule, so as to make the messages at the same address in the same group; acquiring address information of former L-1 messages being processed on the pipeline, and taking the group of the addresses of the former L-1 messages being processed as a first address group; determining a target group by comparing a second address group to which effective addresses of the messages to be processed belong with the first address group; and feeding the messages to be processed selected from the target group into a protocol processing pipeline. According to the method and the device for preprocessing message addresses in the protocol processing pipeline provided by the invention, the addresses that enter a message sequence of the pipeline can be distributed more dispersedly, and the probability that the messages at the same address occurs in the pipeline can be effectively reduced, thereby reducing the pause of the pipeline and improving the system protocol processing speed and the message throughput.