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发明公开
CN105218378A 制备取代联苯的方法 无效 - 驳回

制备取代联苯的方法
摘要：
本发明涉及一种制备式(I)的取代联苯的方法，其中R1为硝基或氨基，R2为氰基、卤素、C1-C4卤代烷基、C1-C4卤代烷氧基或C1-C4卤代烷硫基，n为0-3且R3为氢、氰基或卤素，该方法的特征在于使式(II)的卤代苯(其中Hal为氯或溴)在碱以及由钯和式(III)的双齿磷配体(其中Ar为任选取代的苯基且R4和R5各自为C1-C8烷基或C3-C6环烷基或一起形成可以任选带有C1-C6烷基取代基的2-7员桥)组成的钯催化剂存在下在溶剂或稀释剂中与苯基硼酸(IVa)、二苯基次硼酸(IVb)或(IVa)和(IVb)的混合物反应。
摘要（英）：

The invention relates to a method for producing substituted biphenyls of formula (I), wherein R1 = nitro or amino, R2 = cyano, halide, C1-C4 alkyl halide, C1-C4 alkoxy halide or C1-C4 alkylthio halide, n = 0 to 3 and R3 = hydrogen, cyano or halide, characterized by reacting a halobenzene of formula (Il), wherein HaI represents chlorine or bromine, with a phenyl boronic acid (IVa) of a diphenyl borinic acid (IVb) or a mixture of (IVa) and (IVb) in a solvent or diluent in the presence of a base and of a palladium catalyst which consists of palladium and a bidentate phosphorus ligand of formula (III), wherein Ar represents optionally substituted phenyl and R4 and R5 represent C1-C8 alkyl or C3-C6 cycloalkyl each or together form a two- to seven-membered bridge which can optionally carry a C1-C6 alkyl substituent.

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