The invention belongs to the technical field of electronic circuits, and provides an on-off control circuit of an electronic device. According to the invention, the electronic device adopts the on-off control circuit which comprises an on-off trigger module, an on-off control module and a power supply module, thereby being simple in circuit structure, low in cost and conducive to miniaturization. When a system of the electronic device stays in an on state, a controller outputs control signals and clock signals in a differential time mode if the on-off trigger module continuously receives turn-off trigger actions within a second time period so as to enable the on-off control module to control a power supply chip to stop working, thereby enabling the system to be powered off; and when the system of the electronic device stays in an off state, the on-off control module drives the power supply chip to start working according to turn-on trigger signals outputted by the on-off trigger module if the on-off trigger module receives a turn-on trigger action, thereby enabling the system to be turned on, and being capable of realizing stable and reliable on-off control of the electronic device.