The invention belongs to the field of traditional Chinese medicine extraction and particularly relates to an extraction method of a pharmaceutic preparation function in nourishing blood to relieve restlessness and calming heart to soothe the nerves, and a building method of its prediction model. The extraction method uses extraction rate, geniposide content and spinosin content as inspection indicators, geniposide and spinosin are extracted as maximally as possible by optimizing the extraction time, the types of extraction solvents and usage of extraction solvents, their contents are further measured, and thus giving overall control for the quality of the pharmaceutic preparation and assisting in improving the application safety and stability of the pharmaceutic preparation.