The invention provides an intelligent distribution cabinet and a disinfection method thereof. The intelligent distribution cabinet comprises cabinet bodies. Each cabinet body is provided with a plurality of unit lattices which can be opened and closed independently. The intelligent distribution cabinet further comprises disinfection devices and a control device, wherein the disinfection devices are arranged in the unit lattices respectively; the control device is connected with the disinfection devices, acquires environment information and/or food material information and controls the disinfection devices according to the environment information and/or the food material information. According to the intelligent distribution cabinet, the environment information and/or the food material information is acquired, and the disinfection devices are controlled to conduct disinfection according to the environment information and/or the food material information; Compared with a regular disinfection method in the prior art, the disinfection reliability can be effectively improved, the requirements for disinfecting different kinds of food materials can be met, and security can be guaranteed.