The invention relates to a shifting rod anti-prying mechanism of an anti-theft drawer of a safe box. The shifting rod anti-prying mechanism comprises a cylinder, an irregular-shaped clamping groove, a linear groove and a tension spring of the anti-theft drawer of the safe box, wherein the cylinder is arranged at the top ends of U-shaped grooves of the anti-theft drawer of the safe box; the linear groove is formed in the bottom of the side surface of the anti-theft drawer of the safe box; the irregular-shaped clamping groove is formed between the U-shaped grooves and the linear groove; one end of the tension spring is connected with the anti-theft drawer of the safe box; the shifting rod anti-prying mechanism of the anti-theft drawer of the safe box further comprises a shifting rod device; the shifting rod device is clamped tightly through the function of the tension spring; the top end of the shifting rod device is movably connected to the inside of the U-shaped grooves, and the bottom end of the shifting rod device is movably connected to the inside of the linear groove; the shifting rod device comprises a retractable clamping board and a shifting rod board which are movably connected with each other; the retractable clamping board is movably clamped inside the irregular-shaped clamping groove through the tension spring; the retractable clamping board and the shifting rod board coordinate and act together. The shifting rod anti-prying mechanism is clamped inside the irregular-shaped clamping groove under the action of spring tension, and it is guaranteed that the shifting rod device cannot be pushed or pried open to move the drawer in the completely open or closed state of the anti-theft drawer of the safe box.