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发明公开
CN105339390A 靶向O-乙酰化的GD2神经节苷脂作为针对癌症干细胞的新型治疗和诊断策略 审中-实审

靶向O-乙酰化的GD2神经节苷脂作为针对癌症干细胞的新型治疗和诊断策略
摘要：
本发明涉及用于治疗癌症干细胞(CSC)癌的识别O-乙酰化的-GD2神经节苷脂的抗体。本发明进一步涉及用于治疗CSC癌的包含所述抗体的药物组合物和用于治疗对其有需要的患者中的CSC癌的方法，所述方法包括向所述患者给予所述抗体。本发明还涉及用于诊断CSC的方法和O-乙酰化的-GD2神经节苷脂作为CSC癌的生物标志物的用途。最后，本发明涉及用于预测患有CSC癌的受试者对用本发明的抗体或组合物进行的治疗的应答的方法。
摘要（英）：

The present disclosure relates to an antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer. The present disclosure further concern a pharmaceutical composition comprising said antibody for treating a CSC cancer and a method for treating a CSC cancer in a patient in need thereof, said method comprising administering said antibody to said patient. The present disclosure also relates to a method for diagnosing a CSC and to the use of the 0-acetylated-GD2 ganglioside as a biomarker of CSC cancer. Finally, the disclosure relates to a method for predicting the response of a subject affected with CSC cancer to a treatment with an antibody or a composition of the invention.

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