The invention relates to a novel hot-melt adhesive and a preparation method thereof, particularly to a hot-melt adhesive for bonding or compounding metal materials such as aluminium, stainless steel and the like with PVC (polyvinyl chloride) plastic as well as a preparation method of the hot-melt adhesive. The method mainly comprises steps as follows: specific raw materials and the ratio of the raw materials are designed, specific nylon type copolyamide is prepared in advance, the good bonding performance of the nylon type copolyamide with metals is utilized, then the good bonding characteristic of perchloro-ethylene resin with PVC is combined, the nylon type copolyamide and the perchloro-ethylene resin are sufficiently molten and mixed under the synergistic effect of a related aid through a twin-screw extruder, and the obtained novel hot-melt adhesive has better performance on bonding metals and PVC.