The invention belongs to the field of medicine research and development, relates to a medicine substance, and particularly relates to a medicine substance with effects of promoting blood circulation and stopping bleeding, a preparation method of the medicine substance and related traditional Chinese medicines or natural medicine compounds (such as ginkgo leaf and lotus leaf compounds). The medicine substance contains basic medicine components such as amino acids, phenols, lactones, alkaloids and triterpenes, can be extracted from the honeysuckle and lotus leaf compounds through solvents (such as diluted alcohol), or can be obtained by macroporous adsorption resin through separation and enrichment. Thrombosis model and anti-coagulation model tests verify that the traditional Chinese medicine preparations and the composition thereof have obvious effects of promoting blood circulation and stopping bleeding. The traditional Chinese medicine preparations including extracts and enriched products and the composition thereof and the related compounds can be used for medicines and health products.