The present invention provides a method for verifying accuracy and authenticity of modeling and simulation of a typical effect of an infrared imaging sensor system. Aiming at the problem of verifying and evaluating modeling and simulation of a typical effect of an infrared imaging sensor system, the present invention provides a method for verifying simulation of a typical effect of an infrared imaging sensor based on a full reference image quality evaluation method. The method is characterized in that an infrared shot image of a blackbody target is used as a reference image, for an infrared sensor effect simulation image of an infrared imaging system, an analysis method combining per-pixel comparison and statistical comparison is adopted, evaluation factors such as information entropy, irrelevance, structure similarity and fidelity are comprehensively considered, then a comprehensive evaluation index is formed, and comprehensive verification and evaluation can be performed. The method of the present invention is based on the full reference image quality evaluation method and combines two analysis methods, i.e., per-pixel comparison and statistical comparison, so that the method effectively overcomes the defect that a single analysis method can only verify a part of effect simulation result, therefore, the method is comprehensive and objective in evaluation index, and high in accuracy and credibility.