The invention provides a room temperature cured fluorocarbon coating modified with nano particles and a preparation method of the room temperature cured fluorocarbon coating. The fluorocarbon coating specifically comprises a component A and a component B, wherein the component A comprises, by weight, 30%-45% of FEVE fluorocarbon resin, 20%-30% of nano-titanium dioxide filler, 2%-10% of discoid nano-europium oxide filler, 15%-20% of a solvent as well as a flatting agent, a defoaming agent, a wetting dispersant, a thixotropic agent and pigment which account for 4%-10% of the total mass of the component A; the component B comprises, in percentage by mass, 10%-50% of isocyanate type curing agents and a solvent. The weather resistance of the fluorocarbon coating is further improved through the higher shielding effect of nano-europium oxide for ultraviolet light and the composite effect of nano-titanium dioxide and nano-europium oxide.