The present invention provides a preparation method of a smoking cessation snuff from volatile material with tobacco smell. Smoking is hazardous to health, but quitting smoking is a very difficult process. Many people are attracted to the smell of tobacco, and most of the smell comes from the nicotine. The present invention provides a compound with the tobacco smell to help quit smoking without addiction. The compound is obtained mainly through the following steps: drying and then pulverizing Russula foetens, soaking and extracting with chloroform methanol (1:1 by volume), and concentrating an extract; conducting repeated chromatography on the extract by a silica gel column to obtain a compound monomer; and packaging the monomer with sealed shallow mouth bottles with inner network. The compound is a novel compound first isolated by the method, and provides a solution for smoking cessation.