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发明公开
CN105481760A 衍生化的替比格雷活性代谢产物的制备方法 无效 - 撤回

衍生化的替比格雷活性代谢产物的制备方法
摘要：
本发明属于医药技术领域，公开了一种衍生化的替比格雷活性代谢产物制备方法，以4-氧代-1-三苯甲基哌啶为起始原料，在苯和吡咯烷中反应；随后加入吗啉—四氢呋喃混合液，再加入乙醛酸乙酯的甲苯溶液反应。该方法简便易行，纯度高，收率达65.1％，适合工业化生产。
摘要（英）：

The invention belongs to the technical field of medicine and discloses a preparation method of a derivative tipidogrel active metabolite. According to the preparation method, 4-oxo-1-triphenylmethyl piperidine is taken as a starting material and reacts in benzene and pyrrolidine; then a morpholine-tetrahydrofuran mixed liquid is added, and the mixture is added to a toluene solution of ethyl glyoxalate for reaction. The method is simple and easy, the purity is high, the yield is up to 65.1%, and the preparation method is suitable for industrial production.

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