The invention relates to a device for measuring resistivity and seebeck coefficient and a usage method. The technical scheme is characterized in that: the device consists of an elevation system, a horizontal movement system and a measurement system. A hot end electrode (12) and a cold end electrode (24) are respectively fixed on one end of a horizontal rod (9); the other end of the horizontal rod (9) is connected to a vertical screw rod (7) through a screw nut type sliding block; during the measurement, the clamping electrode (13) horizontally moves a test sample (36) to a position right under the hot end telescopic electric level probe (29) and a cold end telescopic electric level probe (30) through the two sliding blocks which are perpendicular to each other in two moving directions; the voltage, the current and the temperature of various areas to be detected can be read through a high precision digital voltage gauge (34), a high precision digital current gauge (38), a first temperature gauge (35) and a second temperature gauge (37); and the corresponding resistivity and the seebeck coefficient are obtained through calculation. The invention can realize the direct measurement of the resistivity and the seebeck coefficient of the cuboid sample and the circular column sample in various areas, and the measurement accuracy is high.