The invention provides a waterproof and crashproof shell for electronic equipment and a preparation method. The method comprises the following steps: (S1) carrying out 3D hot press working on a flat substrate with a preset thickness, and processing a 3D substrate product with a 3D curved surface; (S2) putting the 3D substrate product into a plastic mold, and molding a plastic assembly structural part on the bottom surface of the 3D substrate product in an integrated injection manner; and (S3) putting the 3D substrate product into a silicone mold, molding an elastic silicone waterproof anti-collision structure layer on the bottom surface and the side surfaces of the 3D substrate product in the integrated injection manner, and exposing a main body part of the plastic assembly structural part outside the elastic silicone waterproof anti-collision structure layer. The shell comprises the 3D substrate product, the plastic assembly structural part and the elastic silicone waterproof anti-collision structure layer; the plastic assembly structural part is molded on the bottom surface of the 3D substrate product in the integrated injection manner; the elastic silicone waterproof anti-collision structure layer is molded on the bottom surface and the side surfaces of the 3D substrate product in the integrated injection manner; and the main body part of the plastic assembly structural part is exposed outside the elastic silicone waterproof anti-collision structure layer. The waterproof and crashproof shell for the electronic equipment can be effectively waterproof and crashproof.