The invention belongs to the field of natural organic chemistry and relates to a purification method of anthocyanin of grape skin, in particular to a method for purifying the anthocyanin of the grape skin with a macroporous resin technology. Inorganic acid is taken as an extraction solution, the extraction is complete, the production efficiency is improved, the method is simple, macroporous resin is convenient and rapid to regenerate and suitable for large-scale production, the cost is greatly reduced, most of impurities are removed through water washing, and the operation is easy; meanwhile, the content of effective ingredients is increased.