The invention discloses a preparation method and a quality control method for peach-kernel-safflower decoction-of-four-ingredients formula granules. The preparation method comprises the steps: distilling chuanxiong rhizome and Chinese angelica so as to extract volatile oil, and carrying out inclusion on the volatile oil by adopting beta-cyclodextrin , so as to prepare a beta-cyclodextrin inclusion compound; adding water, of which the weight is 5 to 15 times the weight of total input, into decoction dregs and the rest decoction pieces, and carrying out decocting extraction twice; carrying out vacuum concentration on filtrate; carrying out spray drying on a concentrated solution so as to obtain spray-dried powder, and crushing the spray-dried powder by adopting a jet mill, so as to obtain superfine powder; uniformly mixing the superfine powder and the beta-cyclodextrin inclusion compound, adding maltodextrin into the mixture, and carrying out dry granulation, thereby obtaining the peach-kernel-safflower decoction-of-four-ingredients formula granules. The quality control method comprises the steps of adopting infrared fingerprint, adopting thin-layer qualitative identification and carrying out HPLC (High-Performance Liquid Chromatography) content assaying. According to the methods disclosed by the invention, the advantage of traditional Chinese medicine matching can be brought into full play, and effective ingredients are reserved to the maximum; a complete quality standard is established, and quality control is carried out by adopting a thin-layer chromatography QAMS (quantitative analysis of multi-components by single marker) technology combined with infrared-spectrum and chromatography methods, so that the quality of the compound granules can be effectively controlled.