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发明公开
CN105601524A LCZ696关键中间体的制备 有权

LCZ696关键中间体的制备
摘要：
LCZ696关键中间体的制备。本发明涉及LCZ696关键中间体(4S,2R)-5-([1,1'-联苯]-4-基)-4-氨基-2-甲基戊酸酯盐酸盐的制备方法。该方法制备的(4S,2R)-5-([1,1'-联苯]-4-基)-4-氨基-2-甲基戊酸酯盐酸盐的两个手性中心均来自于手性片段,不涉及使用昂贵且商业化不易大量采购的金属催化剂和手性配体,容易实现商业化生产。
摘要（英）：

The invention provides preparation of an LCZ696 key intermediate and relates to a preparation method of the LCZ696 key intermediate (4S,2R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride. Two chiral centers of the (4S,2R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride prepared by adopting the preparation method provided by the invention are respectively from chiral fragments, usage of expensive metal catalysts and chiral ligands which are difficult to commercially purchase in bulk is avoided, and commercialized production can be easily realized.

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