The invention belongs to the field of medicine and particularly relates to an intelligent and novel medicine composition having anti-hepatitis B virus activity and a preparation method thereof.The medicine composition contains an enteric magnesium isoglycyrrhizinate sheet core and further contains other types of anti-hepatitis B virus medicine.To be specific, further improvement is made on the basis of the prior art, a dissolution layer is further added outside an enteric magnesium isoglycyrrhizinate coating layer, and unexpectedly, the magnesium isoglycyrrhizinate medicine composition high in dissolution rate and good in bioavailablity is obtained.Furthermore, the dissolution layer is sequentially wrapped by a medicine containing layer and a protection layer, so that a compound preparation is formed, the compound preparation is convenient to take, and patient compliance is greatly improved.