The invention discloses a synthesis method of a chirality covalent organic framework. The method includes the following steps that firstly, a chirality precursor and benzenetricarboxaldehyde are catalyzed by acetic acid under the inert atmosphere to react and generate a solid product, wherein the structural formula of the chirality precursor can be seen in the description, and Boc is t-butyloxycarboryl; secondly, t-butyloxycarboryl is removed from the solid product obtained in the first step to obtain the chirality covalent organic framework material. The chirality covalent organic framework is successfully synthesized, has a large specific area and a regular pore structure, has good catalytic activity and circulation for the asymmetric Aldol reaction of ketone and aldehyde, and is a good multiphase chirality catalyst, and the application range of the molecular sieve material in the field of chirality catalysis is greatly expanded.