The invention discloses a traditional Chinese medicine composition for preventing the foot-and-mouth disease. The traditional Chinese medicine composition is prepared from, by weight, 20-40 parts of radix aconiti lateralis preparata, 10-25 parts of rhizoma zingiberis, 5.5-12.5 parts of ardisia japonica, 7.5-12 parts of radix scutellariae, 4-8 parts of eclipta prostrate, 6-12 parts of radix isatidis, 8-12 parts of herba sedi, 10-25 parts of honeysuckle stem, 9-15 parts of stem and leaf of common yam, 2.5-6 parts of saxifrage, 25-35 parts of cactus and 27-33 parts of licorice root. The invention further discloses a corresponding preparing method and application. The raw materials of the traditional Chinese medicine composition are all pure natural medicinal materials which are free of toxicity or harm, the resistance of livestock to the foot-and-mouth disease can be effectively improved, occurrence of the foot-and-mouth disease can be prevented, and a green screen is provided for breeding enterprises. The traditional Chinese medicine composition is for veterinarian clinical use and can definitely prevent the foot-and-mouth disease from occurring on artiodactyla livestock including pigs, cows and sheep.