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发明公开
CN105669789A 一种去甲万古霉素的制备方法 无效 - 驳回

一种去甲万古霉素的制备方法
摘要：
本发明公开了一种去甲万古霉素的制备方法。该方法首先以超顺磁性微球吸附发酵液中的去甲万古霉素活性组分，经洗脱、结晶、干燥，得到去甲万古霉素粗粉；粗粉再经装有C8填料的色谱柱制备分离，得到纯度大于99%的去甲万古霉素产品。超顺磁性微球对去甲万古霉素的活性组分具有高选择性，该微球介质的引入使纯化工艺大大简化，收率大幅提高；工业色谱分离技术的应用，进一步降低了杂质组分的比例，得到了高纯度的去甲万古霉素产品。本发明操作简便，溶媒消耗少，产品收率高，适合于商业化生产。
摘要（英）：

The invention discloses a preparation method for norvancomycin. The method includes the steps that firstly, norvancomycin active components in fermentation liquor are adsorbed through superparamagetism micro-spheres, and crude norvancomycin powder is obtained after elution, crystallization and drying; the crude powder is prepared and separated through a chromatographic column filled with C8 filler, and the norvancomycin product with the purity larger than 99% is obtained. The superparamagetism micro-spheres have high selectivity for the norvancomycin active components, the purification process is greatly simplified through introduction of the micro-sphere medium, and the yield is greatly increased. Through application of the industrial chromatographic separation technology, the proportion of impurity components is further reduced, and the norvancomycin product with high purity is obtained. The preparation method is easy and convenient to operate, small in solvent consumption, high in product yield and suitable for commercialized production.

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