A revaprazan hydrochloride composition comprises revaprazan hydrochloride, surface active agent and one or more of filler, binder, disintegrant and lubricant serving as auxiliary materials. The composition is characterized in that co-micronization is conducted on revaprazan hydrochloride and the surface active agent till the grain size D90 is 1-10 microns. According to the composition, raw material aggregation and adhesion are avoided, the preparation moldability of the revaprazan hydrochloride raw material is improved, problems such as sticking in industrial production are solved, and the stability of a revaprazan hydrochloride preparation is improved.